The official Twitter account of the show shared a photo of the cast and crew today, with the final episodes due to air later this summer.
The photo shows fan-favourite characters including Karl and Susan Kennedy, Paul Robinson and Jarrod “Toadfish” Rebecchi.
The soap opera, which first aired in Australia in 1985 before coming to the UK the following year.
Jason Donovan and Kylie Minogue, while not featured in the photo, are set to appear in the final episodes after being confirmed to be returning to the roles which made them household names. The pair’s character wed on screen in 1987, with millions tuning in to watch.
— Neighbours (@neighbours) June 10, 2022
The soap has been a staple on Irish TV screens, airing at lunchtime and in the evenings on RTÉ alongside Home & Away.
It has also launched the careers of several Hollywood stars and entertainers, including Kylie Minogue, Russell Crowe, Margot Robbie and Natalie Imbruglia.
Although successful in Melbourne, Neighbours originally underperformed in the Sydney market and was cancelled by Seven four months after it began airing in 1985. It was immediately commissioned by rival network Ten for a second production season, which began screening on 20 January 1986.
Neighbours has since become the longest-running drama series in Australian television history. In 2005, it was inducted into the Logie Hall of Fame.
The storylines concern the lives of the people who live and work in Erinsborough, a fictional suburb of Melbourne, Victoria. The series centres on the residents of Ramsay Street, a cul-de-sac, and its neighbouring area, the Lassiters complex, which includes a bar, hotel, café, police station, lawyers’ office and park.
It was announced earlier this year that Neighbours would cease production in June after failing to secure new funding since being dropped by its broadcaster.