The ex-couple was scheduled to spar tonight at the top of the Burj Al Arab hotel helipadwhich is 700 feet above sea level.
But with less than 24 hours remaining, the death of 73-year-old UAE President Sheikh Khalifa bin Zayed forced the entire event to be ruled out.
Mayweather was hosting the pay-per-view show along with FrontRow and Global Titans Fight Series.
And although the boxing legend has not yet broken his silence, the statement confirmed the postponement.
The statement read: “Out of deep respect and due to the unforeseen circumstances of Force Majeure, the Global Titans Dubai event that was scheduled to be held on May 14 at Burj Al Arab Jumeirah Hotel has been postponed until further notice, with a new date. It will be announced very soon.”
“We apologize for any inconvenience this may cause and assure fans that this amazing event will take place in the future.”
Mayweather himself praised Khalifa, writing: “Send my condolences to all the Emirates. Tore Sheikh Khalifa bin Zayed.”
Pictures revealed that the arena was actually set up just hours before the cancellation with the bottom card fighters in control of it.
But the UAE Ministry of Presidential Affairs announced a 40-day mourning period and suspended work in all ministries for a period of three days.
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This eventually resulted in the Mayweather Show event being postponed without any official word on a rescheduled date.
Khalifa was a leader of the United Arab Emirates from 2004 onwards, and his fortune is believed to be around $120 million.
He is also the half-brother of Sheikh Mansour, the billionaire who bought Manchester City Football Club in 2008.
Mayweather, 45, spent the week in Dubai promoting and training to fight alongside Moore, 42.
Only 20-40 VIP fans were set to attend, as tickets were purchased as NFTs, at a cost equivalent to £150,000.
Mayweather has been set to box in his third bout for the show since he officially retired in 2017 after defeating UFC star Conor McGregor, 33.
First, he faced featherweight kickboxer Tenshin Nasukawa, 23, in 2018 and then YouTuber Logan Paul, 27, last June.