The action begins in the first week when Houston hosts the Indianapolis Colts, also the first game in South Asia this season.
The Governor’s Cup between the Texas and the Dallas Cowboys is Week 14 at AT&T Stadium.
Houston’s season finale will also be against the Colts. The date, time and network of that final will be announced as soon as the end of the eighteenth week.
This is the full schedule, including TV networks.
Troy Taormina – USA TODAY Sports
Texas has not opened against the Colts since 2011.




Isaiah J. Downing-USA Today Sports
Houston hasn’t visited Denver since 2018.




Mike Denovo USA Today Sports
Texans last visited Soldier Field – without fans – in 2020.




(Photo by Carmen Mandato/Getty Images)
The Charger lost to Houston in Week 16 last year.




Bob Self / Florida Times-Union-USA TODAY NETWORK
Texans have not lost to a Jaguar since 2017.




Jerome Meron – USA TODAY Sports
This will be the first time the Texans face Las Vegas.




Troy Taormina – USA TODAY Sports
This is the first time since 2017 that the Texans will open the Titans series at NRG Stadium.




(AP Photo/Dave Einsel)
Houston never beat the Eagles.




Brad Benner USA Today Sports
The Texans’ first game, pre-season or otherwise, was the Pro Football Hall of Fame against the Giants.




(Photo by Bob Levy/Getty Images)
This will be the first time Houston has faced the leaders.




Jasen Vinlove-USA TODAY Sports
Houston hasn’t beaten the Dolphins since 2018.




Ken Tops USA Today Sports
The Browns might have a familiar quarterback in this game.




(AP Photo/Michael Ainsworth)
The only Texas wins were against the Cowboys in prime time (2002, 2018).




(AP Photo/Dave Einsel)
Texans have not defeated the Chiefs since 2016.




Steve Roberts – USA TODAY Sports
The last time Houston played with the Titans was in December 2019 and they won.




(Photo by Bob Levy/Getty Images)
Houston hasn’t been overrun by a Jaguar since 2017.




(Associated Press/Michael Conroy)
The Texans last closed to the 2012 Colts.